Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis

Abstract

OBJECTIVE: Nitric oxide plays an important role in the control of renal blood flow and renal function. In sepsis, increased levels of inducible nitric oxide synthase produce excessive nitric oxide, which may contribute to the development of acute kidney injury. We, therefore, examined the effects of intrarenal infusion of selective inducible nitric oxide synthase inhibitors in a large animal model of hyperdynamic sepsis in which acute kidney injury occurs in the presence of increased renal blood flow. DESIGN: Prospective crossover randomized controlled interventional studies. SETTING: University-affiliated research institute. SUBJECTS: Twelve unilaterally nephrectomized Merino ewes. INTERVEN..